ASUS releases beta BIOS AMD 600 series
Some ASUS X670/B650 already support non-binary DDR5 memory modules
First, a word of advice, those are test BIOSes not intended for public use. So unless absolutely necessary (like you purchased a wrong RAM), there is no reason for anyone to jump on these releases just yet, even if they are working. It is strongly recommended waiting for the official release.
Enthusiasts, however, will be pleased to know that such BIOSes already exist. ASUS in-house overclocker Shamino has confirmed that the first batch of BIOSes for the AMD 600 series are now available. This firmware will enable 24GB and 48GB non-binary DDR5 module support on the platform, a feature that was already teased by an ASUS employee earlier this week.
Among supported platforms are eight X670E and one B650 motherboards. Updates for ROG Strix, Crosshair and Creator motherboards are listed, with no mention of other series.
Officially the AMD 600 platform only supports 128GB capacity, but with new firmware, it should work with 48GB modules per slot. Users could now build AMD 600 systems with up to 192 GB storage.
If one absolutely needs to try this, there is a 50-page-long thread on the ASUS forums. Please read it carefully to be aware of any potential issues.
Source: ASUS ROG Forums via @9550pro